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KMID : 0545120190290010021
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Journal of Microbiology and Biotechnology
2019 Volume.29 No. 1 p.21 ~ p.29
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Anti-Aging Activity of Lavandula angustifolia Extract Fermented with Pediococcus pentosaceus DK1 Isolated from Diospyros kaki Fruit in UVB-Irradiated Human Skin Fibroblasts and Analysis of Principal Components
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Ha Ji-Hoon
Kim A-Rang
Lee Keon-Soo
Xuan Song Hua
Kang Hee-Cheol
Lee Dong-Hwan
Cha Mi-Yeon
Kim Hye-Jin
An Mi
Park Soo-Nam
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Abstract
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The effects of Lavandula angustifolia extracts fermented with Pediococcus pentosaceus DK1 on UVB-mediated MMP-1 expression and collagen decrease in human skin fibroblasts Lavandula angustifolia extract fermented with Pediococcus pentosaceus DK1 were determined on UVB-mediated MMP-1 expression and collagen decrease in human skin fibroblasts and the conversion of its components. Fermentation was performed at varying L. angustifolia extract and MRS medium concentrations, and optimal fermentation conditions were selected. L. angustifolia extracts showed decreased cytotoxicity after fermentation in the fibroblasts. UVB-irradiated fibroblasts treated with fermented L. angustifolia extract showed MMP-1 expression 8.2-14.0% lower than that in UVB-irradiated fibroblasts treated with non-fermented extract. This was observed even at fermented extract concentrations lower than those of nonfermented extracts. Fibroblasts treated with fermented L. angustifolia extract showed 20% less reduction in collagen production upon UVB irradiation than those treated with non-fermented extracts. UVB-irradiated fibroblasts treated with fermented L. angustifolia extracts showed 50% higher inhibition of ROS generation than those treated with non-fermented extract. Luteolin and apigenin glycosides of L. angustifolia were converted during fermentation, and identified using RP-HPLC and LC/ESI-MS. Therefore, the effects of L. angustifolia extract were increased through fermentation by P. pentosaceus on MMP-1 expression and collagen decrease in UVBirradiated human skin fibroblasts.
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KEYWORD
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Pediococcus pentosaceus DK1, fermentation, UVB, matrix metalloproteinase-1, procollagen
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